Gonadotropin-Releasing Hormone Antagonist plus Testosterone: A Potential Male Contraceptive*
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چکیده
منابع مشابه
Regulation of pituitary gonadotropin-releasing hormone receptors by pulsatile gonadotropin-releasing hormone injections in male rats. Modulation by testosterone.
The pattern of the gonadotropin-releasing hormone (GnRH) stimulus is critically important in the regulation of pituitary gonadotropin secretion and continuous infusions down-regulate secretion while intermittent pulses maintain luteinizing hormone (LH) and follicle-stimulating hormone (FSH) responsiveness. We examined the effects of pulsatile GnRH administration on pituitary GnRH receptors (GnR...
متن کاملNovel Male Hormonal Contraceptive Combinations: The Hormonal and Spermatogenic Effects of Testosterone and Levonorgestrel Combined with a 5 -Reductase Inhibitor or Gonadotropin-Releasing Hormone Antagonist
Prince Henry’s Institute of Medical Research and Department of Obstetrics and Gynaecology (K.L.M., R.I.M.), Monash University, Monash Medical Centre, Clayton, Victoria 3168, Australia; The Center for Research in Reproduction and Contraception (J.K.A., R.B., W.J.B.), University of Washington, Seattle, Washington 98195; and School of Physiotherapy (A.U.), University of Melbourne, Parkville, Victo...
متن کاملThe effects of supraphysiological levels of testosterone on neural networks upstream of gonadotropin-releasing hormone neurons
Objective(s): Several pathological conditions are associated with hyper-production of testosterone; however, its impacts are not well understood. Hence, we evaluated the effects of supraphysiological levels of testosterone on gonadotropin-releasing hormone (GnRH) system in the hypothalamus of male rats. Also, we assessed the expression of two excitatory (kisspeptin and...
متن کاملImpact of gonadotropin-releasing hormone antagonist addition on pregnancy rates in gonadotropin-stimulated intrauterine insemination cycles
OBJECTIVES The objective of the study is to evaluate the efficacy of gonadotropin-releasing hormone (GnRH) antagonist in improving clinical pregnancy rate in gonadotropin-stimulated intrauterine insemination (IUI) cycles in patients of unexplained infertility. STUDY DESIGN This was a prospective, randomized case-controlled study. SETTINGS The study was conducted in the infertility clinic of...
متن کاملGonadotropin-releasing hormone analog combined with a low-dose oral contraceptive to treat heavy menstrual bleeding.
OBJECTIVE To compare the effects of low-dose oral contraceptives used alone and in combination with a gonadotropin-releasing hormone (GnRH) analog to treat heavy menstrual bleeding. METHODS Fifty-eight patients with heavy menstrual bleeding were prospectively randomized into two treatment groups to receive either a low-dose oral contraceptive alone (group 1), or combined with a GnRH analog (g...
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ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 1991
ISSN: 0021-972X,1945-7197
DOI: 10.1210/jcem-73-3-465